Molecular organization of the COG vesicle tethering complex

Functional specialization within a vesicle tethering complex

The exocyst is an octameric protein complex required to tether secretory vesicles to exocytic sites and to retain ER tubules at the apical tip of budded cells. Unlike the other five exocyst genes, SEC3, SEC5, and EXO70 are not essential for growth or secretion when either the upstream activator rab, Sec4p, or the downstream SNARE-binding component, Sec1p, are overproduced. Analysis of the suppr...

Vesicle Tethering: TRAPPing Transport Carriers

Transport vesicles must dock with the appropriate acceptor membrane to ensure faithful protein delivery. Recent work identifies some of the molecular mechanisms that contribute to the specificity of this reaction.

formation and evolution of regional organizations: the case study of the economic cooperation organization (eco)

abstract because of the many geopolitical, geo economical and geo strategically potentials and communicational capabilities of eco region, members can expand the convergence and the integration in base of this organization that have important impact on members development and expanding peace in international and regional level. based on quality analyzing of library findings and experts interv...

Investigating the Architecture and Vesicle Tethering Function of the Yeast Exocyst Complex: A Dissertation

The Architecture of the Multisubunit TRAPP I Complex Suggests a Model for Vesicle Tethering

Transport protein particle (TRAPP) I is a multisubunit vesicle tethering factor composed of seven subunits involved in ER-to-Golgi trafficking. The functional mechanism of the complex and how the subunits interact to form a functional unit are unknown. Here, we have used a multidisciplinary approach that includes X-ray crystallography, electron microscopy, biochemistry, and yeast genetics to el...